PF-04859989 HCl

CAS No. 177943-33-8

PF-04859989 HCl ( PF-04859989HCl; PF-04859989; PF 04859989; PF04859989 )

Catalog No. M27913 CAS No. 177943-33-8

PF-04859989 HCl is a brain-penetrable and irreversible inhibitor of kynurenine amino transferase II (KAT II), which is the enzyme responsible for most of the brain synthesis of kynurenic acid.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 40 Get Quote
5MG 63 Get Quote
10MG 104 Get Quote
25MG 203 Get Quote
50MG 327 Get Quote
100MG 509 Get Quote
200MG 614 Get Quote
500MG 894 Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    PF-04859989 HCl
  • Note
    Research use only, not for human use.
  • Brief Description
    PF-04859989 HCl is a brain-penetrable and irreversible inhibitor of kynurenine amino transferase II (KAT II), which is the enzyme responsible for most of the brain synthesis of kynurenic acid.
  • Description
    PF-04859989 HCl is a brain-penetrable and irreversible inhibitor of kynurenine amino transferase II (KAT II), which is the enzyme responsible for most of the brain synthesis of kynurenic acid.(In Vitro):The IC50s values are 23 and 263 nM for hKAT II and rKAT II. PF-04859989 HCl is selective for KAT II over human KAT I, KAT III, and KAT IV (IC50s of 22, 11, and >50 μM, respectively).(In Vivo):Acute administration of the KAT II inhibitor PF-04859989 (5 or 10 mg/kg) was associated with a short-onset, time-dependent decrease in firing rate and burst activity of DA neurons, both parameters reaching a 50% reduction within 45 min. Furthermore, PF-04859989 reduced the number of spontaneously active DA cells as measured 4-6 after administration. Pretreatment with d-cycloserine (30 mg/kg) or CGP-52432 (10 mg/kg) prevented the inhibitory action of PF-04859989 (5 mg/kg) on firing rate and burst firing activity. In contrast, pretreatment with methyllycaconitine (MLA, 4 mg/kg) did not change the response, whereas picrotoxin (4.5 mg/kg) partially prevented the inhibitory effects of PF-04859989 (5 mg/kg, i.v.).
  • Synonyms
    PF-04859989HCl; PF-04859989; PF 04859989; PF04859989
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    myeloperoxidase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    177943-33-8
  • Formula Weight
    286.9
  • Molecular Formula
    C7H6BrCl2NO2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    Cl.[O-][N+](=O)c1cccc(Cl)c1CBr
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Arvadia P, et al. 4-Aminobenzoic acid hydrazide inhibition of microperoxidase-11: catalytic inhibition by reactive metabolites. Arch Biochem Biophys. 2011 Nov;515(1-2):120-6.
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