PF-04859989 HCl
CAS No. 177943-33-8
PF-04859989 HCl ( PF-04859989HCl; PF-04859989; PF 04859989; PF04859989 )
Catalog No. M27913 CAS No. 177943-33-8
PF-04859989 HCl is a brain-penetrable and irreversible inhibitor of kynurenine amino transferase II (KAT II), which is the enzyme responsible for most of the brain synthesis of kynurenic acid.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
2MG | 40 | Get Quote |
|
5MG | 63 | Get Quote |
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10MG | 104 | Get Quote |
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25MG | 203 | Get Quote |
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50MG | 327 | Get Quote |
|
100MG | 509 | Get Quote |
|
200MG | 614 | Get Quote |
|
500MG | 894 | Get Quote |
|
1G | Get Quote | Get Quote |
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Biological Information
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Product NamePF-04859989 HCl
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NoteResearch use only, not for human use.
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Brief DescriptionPF-04859989 HCl is a brain-penetrable and irreversible inhibitor of kynurenine amino transferase II (KAT II), which is the enzyme responsible for most of the brain synthesis of kynurenic acid.
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DescriptionPF-04859989 HCl is a brain-penetrable and irreversible inhibitor of kynurenine amino transferase II (KAT II), which is the enzyme responsible for most of the brain synthesis of kynurenic acid.(In Vitro):The IC50s values are 23 and 263 nM for hKAT II and rKAT II. PF-04859989 HCl is selective for KAT II over human KAT I, KAT III, and KAT IV (IC50s of 22, 11, and >50 μM, respectively).(In Vivo):Acute administration of the KAT II inhibitor PF-04859989 (5 or 10 mg/kg) was associated with a short-onset, time-dependent decrease in firing rate and burst activity of DA neurons, both parameters reaching a 50% reduction within 45 min. Furthermore, PF-04859989 reduced the number of spontaneously active DA cells as measured 4-6 after administration. Pretreatment with d-cycloserine (30 mg/kg) or CGP-52432 (10 mg/kg) prevented the inhibitory action of PF-04859989 (5 mg/kg) on firing rate and burst firing activity. In contrast, pretreatment with methyllycaconitine (MLA, 4 mg/kg) did not change the response, whereas picrotoxin (4.5 mg/kg) partially prevented the inhibitory effects of PF-04859989 (5 mg/kg, i.v.).
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SynonymsPF-04859989HCl; PF-04859989; PF 04859989; PF04859989
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PathwayOthers
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TargetOther Targets
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Recptormyeloperoxidase
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Research Area——
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Indication——
Chemical Information
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CAS Number177943-33-8
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Formula Weight286.9
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Molecular FormulaC7H6BrCl2NO2
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Purity>98% (HPLC)
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Solubility——
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SMILESCl.[O-][N+](=O)c1cccc(Cl)c1CBr
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Arvadia P, et al. 4-Aminobenzoic acid hydrazide inhibition of microperoxidase-11: catalytic inhibition by reactive metabolites. Arch Biochem Biophys. 2011 Nov;515(1-2):120-6.
molnova catalog
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